A 12-month randomised, double-blind, controlled, international multicentre trial comparing changes in cigarette consumption after switching to high or low nicotine strength e-cigarettes in smokers with Schizophrenia spectrum disorders. This will be a multicenter, 12-months prospective trial, utilizing a randomized, double-blind, 2-arm parallel, switching design to compare effectiveness, tolerability, acceptability, and pattern of use between high (JUUL 5% nicotine) and low nicotine strength devices (JUUL 1.5% nicotine) in adult smokers with schizophrenia spectrum disorders. The study will take place at 5 sites: 1 in the UK (London) and possibly 4 in Italy.
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